Alaskan Malamute polyneuropathy (AMPN)
Polyneuropathy causes undersupply of the peripheric nervous system followed by nerve degeneration. Due to the lack of nervous stimulation the muscles degrade gradually. The causal mutation in Alaskan Malamute differs from the known mutation in Greyhound breed. The Mutation in Alaskan Malamute has been investigated by Prof. Dr. Merete Fredholm together with an international team of researchers.
The onset of clinical symptoms occurs during the first two years of a dog's life. These symptoms include progressive amyosthenia, exercise intolerance, loss of reflexes and ataxia of all limbs. So, the dog may fall down, walk on the tops of his feet or his gait may just look a little off. When palsy affects the larynx, changes in voice and problems in swallowing and regurgitating have also been described. The general condition is not influenced by the disease.
There are some other spinal or neurological problems that may cause similar symptoms, so it may often be misdiagnosed or undiagnosed.
LABOKLIN offers the genetic test for this disease by courtesy of Prof. Fredholm.
Trait of inheritance
1-2 weeks after arrival of the sample in the lab
The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.
Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.
Please contact our molecular biology team for further questions.
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D-97688 Bad Kissingen
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Fax: +49 (0)971 68546