Canine leukocyte adhesion deficiency " "(CLAD) ""in Irish Setter and Irish Red- and White Setter

Canine leukocyte adhesion deficiency (CLAD)


Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease found in Irish Setters. The condition is caused by mutation in a gene encoding a leucocyte surface molecule, leading to a dysfunction of the granulocytes. Therefore, the cell-cell adhesion events are disturbed.
Because their healing capacities are impaired, the affected dogs show severe infections of omphalophlebitis, skin infections, osteomyelitis and gingivitis. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics.


Irish Setters; Irish Red and White Setters

Trait of inheritance


Test duration

3-5 days after arrival of the sample in the lab


The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.

Testing procedure

Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.


Please contact our molecular biology team for further questions.

Steubenstraße 4
D-97688 Bad Kissingen

Telefon: +49 (0)971 72020
Fax: +49 (0)971 68546


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