Cystinuria is an inherited disorder caused by a defective transport of the amino acid cystine in the kidney tubules. Normally, cystine is filtered in the kidney and reabsorbed within the tubules, resulting in little cystine in the urine. Dogs with Cystinuria do not properly reabsorb the cystine (and a few other amino acids) in the kidney tubules, causing the urine to contain abnormally high levels of cystine. Cystine is insoluble in neutral pH or acidic urine, so excess urinary cystine results in the formation of crystals, which in turn can lead to formation of cystine calculi (stones) in the kidney and/or the bladder. Dogs suffering from Cystinuria suffer repeated urinary tract inflammations, and are at risk for urinary blockage, which can, if not treated promptly, lead to kidney failure, bladder rupture, and death. In Australian Cattle Dogs the disease is inherited as a dominant trait whereby homozygous affected dogs has more severe symptoms than heterozygous carriers.
Australian Cattle Dog, Labrador Retriever, Landseer, Miniature Pinscher and Newfoundland
Trait of inheritance
autosomal-recessive - Labrador Retriever, Landseer, Newfoundland
autosomal-dominant - Australian Cattle Dog, Miniature Pinscher
3-5 days after arrival of the sample in the lab - Landseer, Newfoundland
1-2 weeks after arrival of the sample in the lab - Australian Cattle Dog, Labrador Retriever, Miniature Pinscher
The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.
Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.