Factor XI deficiency (F11)

Coagulation factor XI is a plasma protein which is involved in the intrinsic blood coagulation... more
Disease
Coagulation factor XI is a plasma protein which is involved in the intrinsic blood coagulation cascade. In contrast to haemophilia, bleeding tendency in factor XI deficiency is only slightly increased. Haematomas and other minor bleeding are typical which only occur sometimes after trauma or surgery. Factor XI deficiency prolongs the partial thromboplastin time in plasma, but the prothrombin time remains normal.
LABOKLIN has studied Maine Coon cats with an increased bleeding tendency as well as their relatives and identified a genetic defect in factor XI. This has also led to the detection of homozygous affected cats as well as carriers in Europe. Factor XI deficiency is inherited in an autosomal recessive manner. This genetic test can be used to reliably identify Maine Coon cats with an increased risk of bleeding, but also asymptomatic male and female carriers, and thus limit the transmission of this genetic defect in breeding.
Breed
Maine Coon
Heredity
autosomal recessive
Test duration
3-5 days after arrival of the sample in the lab
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