K-lokus and K-locus brindle*
Characteristic and trait of inheritance
The K locus plays a crucial role in coat colour determination. The findings for it are relative new and changed the understanding of canine colour, as the K-locus includes traits formerly attributed to other genes.
KB is the dominant allele, which leads to expression of single coloured fur in pigmented areas. This trait was formerly attributed to AS of the Agouti (A) locus. There are two other alleles, kbr and ky. KB is dominant to both kbr and ky, while kbr is dominant only to ky. kbr is responsible for the brindle pattern. The recessive allele ky allows the basic patterns of the A locus to be expressed. Same does the kbr allele, but with brindling of any tan, fawn, or tawny areas. Any animal with at least one KB allele will be single-colored in the pigmented areas.
Test for KB and ky:
LABOKLIN presently tests for these two alleles. In some breeds, where no brindle is present, this represents a complete analysis of the locus (e.g. the pug). In breeds where the standard disqualifies all but single-colored dogs, testing for these two alleles is sufficient as well. Any animal with two KB alleles cannot produce anything except single-coloured offspring. (e.g. the Labrador Retriever). In breeds where many variations are allowed, these tests can help predict the probability of potential litters to include fawn, sable, tawny, tan point, tricolor or recessive black puppies.
The test LABOKLIN offers at the moment detects the KB and the ky allels only. The kbr allel can't be analysed with this test.
K-locus: 1-2 weeks after arrival of the sample in the lab
K-locus brindle*: Please note: LABOKLIN doesn't send samples away for the brindle-test anymore. The test for K-locus by LABOKLIN only analyses the KB and ky allels. No statement for existence or absence of a kbr allel can be derived from this test.
The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.
Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.