NCL is a neurodegenerative disease: the clinical course includes increasing levels of agitation... more
NCL is a neurodegenerative disease, caused by lysosomal storage dysfunction. The clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.
3-5 days after arrival of the sample in the lab (American Bulldog, Australian Shepherd, Border Collie, English Setter, Gordon Setter, Tibetan Terrier); 1-2 weeks (Chinese Crested Dog, Chihuahua, Dachshund, Saluki)