MDR1-gene defect(Ivermectin hypersensibility) ***

Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a... more
Disease
Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a prominent member of the avermectin family, is a drug that is used extensively in veterinary medicine to treat infections caused by nematode and arthropod parasites. Although ivermectin is generally safe for use in domestic animals, in the 1980s a number of clinical cases with neurological manifestation have been reported after ivermectin treatment. Neurotoxic symptoms include mydriasis, tremors, ataxia and anorexia. These symptoms occur at doses that are 1/200th of the dose required to cause toxicity in other dogs. Neurological manifestations of ivermectin in susceptible dogs also include hypersalivation, blindness, coma respiratory compromise and death.
Breed
Australian Shepherd, Border Collie, Collie (rough/smooth), Elo, German Shepherd, Long-Haired Whippet (Silken Windsprite), McNab Shepherd / Border Collie, Miniature Australian Shepherd, Old English Sheepdog, Shetland Sheepdog (Sheltie), Silken Windhound, White Swiss Shepherd, Wäller
Heredity
autosomal recessive
Test duration
1-2 weeks after arrival of the sample in the lab
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