The Acral mutilation syndrome (AMS) is characterized by a sensory neuropathy of the peripheral parts of the body, such as limbs, fingers or toes. Affected puppies show an insensitivity to pain in their distal extremities. However, the disease often emerges not until the age of about 4 months, when puppies begin to lick, bite or even self-mutilate their distal extremities. The proprioception, motor abilities and spinal reflexes remain intact. Moreover, the pain perception becomes progressively normal above the knees and is not altered in the rest of the body. Some affected dogs show only insensitivity to pain but no self-mutilation, making diagnosis extremely difficult.
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3-5 days after arrival of the samples in the lab