DNA-Profiling

Webflyer: "Premium SNP DNA profile (ISAG 2020)"

Premium SNP DNA profile (ISAG 2020)

The Premium SNP DNA-profile (ISAG 2020) is your animal's genetic fingerprint. It cannot be manipulated or destroyed, remains unchanged for a lifetime and allows unambiguous identification of the individual. All DNA-profiles are stored in our DNA database, thus ensuring continuous availability. The Premium SNP DNA-profile (ISAG 2020) follows the recommended ISAG (International Society for Animal Genetics) guidelines from 2020 by analyzing 230 SNPs (single nucleotide polymorphisms) and enables international comparability between laboratories. Each SNP marker describes a specific location on the DNA. Test reliability and exclusion probabilities for parentage analysis are well over 99.99%. The Premium SNP DNA profile (ISAG 2020) also has the potential to solve parentage cases where only one parent is available (breeds on request) and furthermore allows an analysis of the genetic diversity (heterozygosity) of a dog with breed-specific evaluation (for clubs on request).

Please note: Premium SNP DNA-profile (ISAG 2020) and Classic STR DNA profiles (ISAG 2006) are not compatible and cannot be used simultaneously within the same parentage analysis.

Species

dog

Breed

all breeds

Test duration

4-6 weeks after arrival of the sample in the lab


Genetic variability (heterozygosity)

Findings – an example

This graph shows the genetic variability (heterozygosity) of your animal. Heterozygosity describes the percentage of genetic markers (SNPs) for which your dog has inherited different variants from its mother and its father. According to current scientific knowledge, dogs with a high degree of heterozygosity within a breed are less often affected by inbreeding than dogs with a low degree of heterozygosity. For the calculation of heterozygosity, we use the genetic fingerprint (the Premium SNP DNA profile) and hundreds of other genetic markers in your dog’s DNA. In the graph, your dog is marked with a cross and a black solid line. Once LABOKLIN has examined a sufficiently large reference population for your breed, you can see the genetic variability of the entire breed population as an area shaded in orange. The mean value of the breed is marked as a grey dashed line. Small population sizes and inbreeding can decrease the heterozygosity of a breed. When breeding, animals with a high degree of heterozygosity within their breed might thus contribute to the preservation of the breed’s genetic diversity. However, please note that heterozygosity cannot be used to draw any conclusions about individual factors such as genetic diseases or characteristics like coat colour. Maintaining genetic variability can be a building block in responsible dog breeding, but it should not be viewed in isolation.

 

FAQs on Genetic Variability (Heterozygosity)

What is genetic variability (heterozygosity)?

How do we calculate the value for heterozygosity?

Where can I see my dog’s heterozygosity in the Premium SNP DNA profile findings?

What does the axis label of the graph in the Premium SNP DNA profile mean?

My report does not show a curve in the graph, why?

How do I interpret values when I do not see a curve in the graph?

In my findings, what does the curve in the graph mean?

What is the meaning of high or low heterozygosity values when compared to the breed population curve?

How can I use the information about the genetic variability (heterozygosity) when I want to breed?

Which test do I need to order to have my animal’s heterozygosity tested?

Which sample material is needed?

How long does it take before I get the results?

Can I draw any conclusions on genetic diseases or coat colours?

FAQ LABOGEN DIVERSITY CHECK (https://diversity.labogen.com)

What is the Labogen Diversity Check?

What distinguishes the Labogen Diversity Check?

How do I use the activation code on my findings? How do I register for the Labogen Diversity Check?

What is the difference between breed distribution and club distribution?

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