von Willebrand disease (vWD) general information
The most common form of canine hereditary bleeding disorders is the von Willebrand disease (vWD). The condition is caused by a quantitative or qualitative deficiency of von Willebrand factor (vWF), which is an essential component of the blood coagulation cascade. A defect of the vWF leads to uncontrolled bleeding upon inquiries or spontaneous. Clinical symptoms of vWD are highly heterogeneous from mild bleeding to severe life-threatening blood loss and may be aggravated by mental or physical stress.
Typical signs are: repeated gastrointestinal bleeding with or without diarrhea, epistaxis, bleeding after dental extraction, gingival bleeding, ecchymosis, extended bleeding during heat, lameness due to bleeding inside the joints, excessive bleeding upon nail cutting or docking or postoperative.
VWD is divided into three major categories: type 1, type 2 and type 3 (find links to the test description below).
von Willebrand disease type 1 (vWD 1)
in Bernese Mountain Dog, Coton de Tulear, Doberman, Drentsche Patrijschond, German Pinscher, Kerry Blue Terrier, Labradoodle, Manchester Terrier, Papillon, Pembroke Welsh Corgi, Poodle and Stabyhound
von Willebrand disease type 2 (vWD 2)
in German Shorthaired Pointers and German Wirehaired Pointers
von Willebrand disease type 3 (vWD 3)
in Dutch Kooiker, Scottish Terrier, Shetland Sheepdog