Locus D (dilution)

The D-locus influences distribution of all pigments causing coat colour dilution. Common names...plus
Disease
The D locus is the primary locus associated with diluted pigment. A recessive mutation is the cause of colour dilution phenotypes in the dog. Two alleles (variants) were described: the dominant full colour (D) and the recessive diluted colour (d). Two copies of dilute are needed to lighten black pigment to grey (often called blue), brown pigment to silver or isabella and red pigment to cream (also called buff). A diagnostic DNA test identifies the specific variants of the MLPH gene.
At the moment, two genetic variations (d1 and d2) are known which independently can result
the diluted coat colour. d1 could be found in all breeds whereas d2 only has been identified
at the breeds Chow Chow, Thai Ridgeback Dog and Sloughi. In these breeds, the tests for
d1 and d2 are recommended.
Breed
Alle Rassen
Heredity
autosomal recessive
Test duration
3-5 days after arrival of the sample in the lab
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