Dystrophie musculaire (MD)

Dogs affected by Muscular Dystrophy show raised creatine kinase levels, muscle atrophy with...plus
Disease
Muscular dystrophy (MD) in Cavalier King Charles Spaniel, Golden Retriever and Norfolk Terrier is a spontaneous, X-linked, progressively fatal disease of dogs and is also a homologue of Duchenne muscular dystrophy (DMD). Affected dogs show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. Landseer muscular dystrophy (LSMD), in difference, is inherited as an autosomal recessive trait. Affected dogs exhibit a general, whole body muscular weakness, they move slowly and clumsy and some cannot walk at all. First symptoms in the course of movement appear at the age of three to six month. Affected dogs usualy die between the ages of 4 and 24 months.
Breed
Cavalier King Charles Spaniel, Landseer, Norfolk Terrier, Retriever Golden
Heredity
X-chromosomal recessive (Cavalier King Charles Spaniel, Golden Retriever, Norfolk Terrier) autosomal recessive (Landseer)
Test duration
1-2 weeks after arrival of the sample in the lab (Cavalier King Charles Spaniel, Golden Retriever, Norfolk Terrier) 3-5 days after arrival of the sample in the lab (Landseer)
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