Myopathie centronucléaire (CNM)

Affected dogs lack tendon reflexes and gain less weight than puppies of the same age.
Centronuclear myopathy (CNM) in Labrador Retrievers, formerly known as hereditary myopathy in Labrador Retrievers (HMLR), was described in the 1970ies for the first time. CNM as a disease causes dysplasia of the dogs muscles. Therefore, affected dogs lack tendon reflexes and gain less weight than puppys of the same age (4 weeks). Obvious symptoms of HMLR first occur at weeks 12 to 20 and include general amyosthenia, aberrant bearing, awkward gait and trouble with ingestion. Affected animals exhibit low stamina and collapse when exposed to coldness. Stress causes amyotrophia, that affects head muscles at times. The same disease appears in Great Danes. 
In German Hunting Terriers a mutation with similar symptoms has been found. At German Hunting Terriers, the disease is also called Exercise induced myopathy (EIM) and is caused by an autosomal-recessive inherited metabolic disorder. Affected dogs show muscular pains and  muscle weakness in situations of stress and physical effort and therefore could not be used as hunting dogs. Nevertheless, affected dogs are able to resume a normal life as a family pet as long as they are not exposed to high physical demands. 
Dogue allemand, Retriever du Labrador, Terrier de chasse allemand
autosomal recessive
Test duration
1-2 weeks after arrival of the sample in the lab (German Hunting Terrier, Great Dane); about 1 week after arrival of the sample in the lab (Labrador Retriever)
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