AHE is associated with multifocal central nervous system deficits including seizures, altered...plus
A fatal brain disease known as Alaskan Husky encephalopathy (AHE) is found in Husky breeds. The disorder correlates to the Leigh syndrome (LS) found in humans, that includes a group of diseases with heterogenous clinical symptoms. For AHE affected dogs clinical findings consist of multifocal central nervous system deficits including seizures, altered mentation, dysphagia, absent menace response, central blindness, hypermetria, proprioceptive positioning deficits, facial hypoalgesia, ataxia and tetraparesis. In contrast to LS in humans, AHE in dogs is not a primary mitochondrial encephalopathy, but correlates with a genetic defect in a thiamine transporter.
1-2 weeks after arrival of the sample in the lab