Déficit immunitaire combiné sévère (SCID)

The severe combined immunodeficiency (SCID) is associated with very low levels of immunoglobulins...plus
Disease
The severe combined immunodeficiency (SCID) is associated with very low levels of immunoglobulins and lymphocytes and therefore causes serious failing in cellular and humoral immunity. Affected dogs show increased susceptibility for viral and bacterial pathogens and die of opportunistic infection at the age of 8 – 12 weeks. The causal mutation in Frisian Water Dogs is a point mutation in the RAG1 gene, while in Jack Russell Terriers there is a point mutation in the canine DNA-PKcs gene.
Breed
Chien d'eau frisan, Terrier du reverend Russell, Terrier Jack Russell
Heredity
autosomal recessive
Test duration
1-2 weeks after arrival of the sample in the lab
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