Copper toxicosis in Bedlington Terriers is based on a disturbance of the copper metabolism,... altro
Copper toxicosis in Bedlington Terriers is based on a disturbance of the copper metabolism, resulting in an accumulation of copper in the liver and other organs. Copper accumulates in the cells where it damages mitochondria, due to the malfunction of its revulsion by the gall. This causes cell death, chronic hepatitis and cirrhosis of the liver. In some cases, necrosis of the liver occurs which leads to the release of copper in the bloodstream followed by haemolysis. The late onset of symptoms in affected dogs results from a tardily process damaging the organs. Uptake of zinc and special drugs abate the symptoms. The genetic test identifies a mutation, which represents a major risk factor for the development of the disease.
1-2 weeks after arrival of the sample in the lab