MDR1 gene variant-Ivermectin hypersensibility ***

Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a... altro
Disease
Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a prominent member of the avermectin family, is a drug that is used extensively in veterinary medicine to treat infections caused by nematode and arthropod parasites. Although ivermectin is generally safe for use in domestic animals, in the 1980s a number of clinical cases with neurological manifestation have been reported after ivermectin treatment. Neurotoxic symptoms include mydriasis, tremors, ataxia and anorexia. These symptoms occur at doses that are 1/200th of the dose required to cause toxicity in other dogs. Neurological manifestations of ivermectin in susceptible dogs also include hypersalivation, blindness, coma respiratory compromise and death.
Dogs with the MDR1 gene variant suffer from multiple intolerance of drugs. An interaction with the multi-drug-resistence-transporter (MDR1) has been proven for more than 100 drugs.
Breed
Australian Shepherd, Border Collie, Collie (rough/smooth), Elo, German Shepherd Dog, McNab Shepherd, Miniature American Shepherd, Old English Sheepdog, Shetland Sheepdog (Sheltie), Silken Windhound, Silken Windsprite (Long-Haired Whippet), White Swiss Shepherd Dog, Wäller
Heredity
autosomal recessive
Test duration
3-5 days after arrival of the sample in the lab
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