Afibrinogenemia (AFG)

Typical signs of bleeding disorders are prolonged clotting time, cord or mucosal bleeding and... altro
Disease
Typical signs of bleeding disorders are prolonged clotting time, cord or mucosal bleeding and haematomas. They can lead to uncontrolled severe bleeding upon surgeries, injuries or spontaneous.
In Dachshunds, a genetic variant of the FGA (fibrinogen alpha chain) gene has been found to be associated with afibrinogenemia, leading to a severe form of bleeding tendency. Afibrinogenemia is characterized by the absence of coagulation factor I (fibrinogen), a glycoprotein with a central role in the final step of coagulation cascade in hemostasis. Affected dogs show extremely prolonged clotting times at different coagulation tests (PT, aPTT, TT), normal activities of factors II, V, VII and X, and normal platelet counts.
Breed
Dachshund (Dackel), Long-Haired Dachshund, Short-Haired Dachshund, Wire-Haired Dachshund
Heredity
autosomal recessive
Test duration
1-2 weeks after arrival of the sample in the lab
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