MDR1 gene variant-Ivermectin hypersensibility ***

Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a... more
Заболевание
Avermectins are a class of natural products with broad antiparasitic activity. Ivermectin, a prominent member of the avermectin family, is a drug that is used extensively in veterinary medicine to treat infections caused by nematode and arthropod parasites. Although ivermectin is generally safe for use in domestic animals, in the 1980s a number of clinical cases with neurological manifestation have been reported after ivermectin treatment. Neurotoxic symptoms include mydriasis, tremors, ataxia and anorexia. These symptoms occur at doses that are 1/200th of the dose required to cause toxicity in other dogs. Neurological manifestations of ivermectin in susceptible dogs also include hypersalivation, blindness, coma respiratory compromise and death.
Dogs with the MDR1 gene defect suffer from multiple intolerance of drugs. An interaction with the multi-drug-resistence-transporter (MDR1) has been proven for more than 100 drugs.
Порода
австралийская овчарка, бордер-колли, колли, эло, немецкая овчарка, длинношерстный уиппет, макнаб, миниатюрная австралийская овчарка, бобтейл (староанглийская овчарка ), шелти (шетландская овчарка), шелковистый виндхаунд, белая швейцарская овчарка, валлер
Тип наследования
autosomal recessive
Длительность теста
1-2 weeks after arrival of the sample in the lab
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