Dilatative Kardiomyopathie (DCM)

Dilated cardiomyopathy is a disease of the heart muscle. Due to the disease, the left ventricle... more
Dilated cardiomyopathy is a disease of the heart muscle. Due to the disease, the left ventricle (the heart‘s main pumping chamber) is enlarged, dilated and weak, so that the heart is not able to pump the blood effectively.

In the breed Welsh Springer Spaniel, a genetic variant of the phospholamban gene has been found to be associated with DCM. Phospholamban plays an important role in regulating the intracellular calcium concentration and therefore the cardiac contraction and relaxation. Left ventricular dilation, poor systolic function, arrhythmia and sudden cardiac death are typical symptoms of affected dogs. Usually, the symptoms become visible until the age of 20 months. The disease is inherited in an autosomal dominant manner with variable penetrance. Compared to other canine cardiac diseases, the dilated cardiomyopathy in the Welsh Springer Spaniel has a high penetrance. This means, that almost every dog carrying the variant shows symptoms at the relevant age.

In the breeds Manchester Terrier and English Toy Terrier, an autosomal recessive variant in the cardiac ATP-sensitive potassium channel gene ABCC9 gene was found to be associated with DCM. DCM can lead to sudden death of the affected dog, which happens before 2 years of age, typically by 6 months. In the acute form, the heart is macroscopically normal, a histopathological examination shows of acute multifocal myocardial degeneration and necrosis without inflammation. In the chronic form, clinical signs like a mild cardiomegaly, left ventricle dilation, left ventricular wall thickening, and left auricle enlargement are common. Additional histopathological findings are myocardial degeneration, myocardial fibrosis, mild inflammation, and sometimes also myocardial mineralization. The disease is inherited in an autosomal recessive manner. The dogs appear healthy prior to sudden death, with reports of anaesthetic events or exercise preceding death in some cases.
English Toy Terrier, манчестер-терьер, новошотландский ретривер, вельш-спрингер-спаниель
Тип наследования
Welsh Springer Spaniel: autosomal dominant, variable penetrance

Manchester Terrier, English Toy Terrier, Nova Scotia Duck Tolling Retriever: autosomal- recessive
Длительность теста
1-2 weeks after arrival of the sample in the lab
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