von Willebrand disease type I (vWD1)

Die von Willebrand Erkrankung (vWD) ist die häufigste vererbte Blutgerinnungs-störung von... more
The most common form of canine hereditary bleeding disorders is the von Willebrand disease (vWD). The condition is caused by a quantitative or qualitative deficiency of von Willebrand factor (vWF), which is an essential component of the blood coagulation cascade. A defect of the vWF leads to uncontrolled bleeding upon inquiries or spontaneous. Clinical symptoms of vWD are highly heterogeneous from mild bleeding to severe life-threatening blood loss and may be aggravated by mental or physical stress. Typical signs are: repeated gastrointestinal bleeding with or without diarrhea, epistaxis, bleeding after dental extraction, gingival bleeding, ecchymosis, extended bleeding during heat, lameness due to bleeding inside the joints, excessive bleeding upon nail cutting or docking or postoperative. VWD is divided into three major categories: type 1, type 2 and type 3 as well as diverse subtypes. Type 1 of vWD is described as the mildest, most common vWD variant in dogs. A high prevalence of about 70 % exists in Doberman Pinschers.
бернский зенненхунд, котон-де-тулеар, доберман, дрентский патрийсхонд, немецкий пинчер, ирландский красно-белый сеттер, ирландский сеттер, керри-блю-терьер, кромфорлендер, лабрадудль (лабрадудель), манчестер-терьер, папийон (папильон), вельш-корги пемброк, пудель, стабихун, вельш-корги
Тип наследования
autosomal dominant with variable penetrance
Длительность теста
3-5 days after arrival of the sample in the lab
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