Congenital myasthenic syndrome (CMS)
Symptoms of the disease are most of all a generalized skeletal muscle weakness, which worsens... more
Заболевание
The congenital myasthenic syndrome (CMS) is caused by a mutation in the COLQ gene in Labrador Retrievers, while in Jack Russell Terriers a mutation in the CHRNE gene is responsible. A genetic defect in the CHAT gene is the cause in the Old Danish Pointer. Symptoms of the disease are most of all a generalized skeletal muscle weakness, which worsens especially after exercise, stress or excitement. Signs can already be seen at just two weeks of age. Mobility of all limbs is reduced, and the ability to bear the own body weight diminishes with time. In all limbs, spinal reflexes are reduced.
Порода
золотистый ретривер (голден-ретривер),
джек-рассел-терьер,
лабрадор-ретривер,
стародатский пойнтер (стародатская легавая ),
парсон-рассел-терьер
Тип наследования
autosomal recessive
Длительность теста
1-2 weeks after arrival of the samples in the lab
