Hemophilia B (factor IX deficiency)
The underlying pathomechanism of haemophilia B is a lack or decreased activity of factor IX that... more
Haemophilia B is one of the most important inherited disorders of haemostasis in Rhodesian Ridgeback Dogs. The underlying pathomechanism of haemophilia B is a lack or decreased activity of factor IX that plays a critical role in the coagulation cascade. Affected dogs present with hemorrhage that can vary from mild to severe depending on the degree of the disease. The clinical signs include haematomas of large sizes, bleeding of the nose, skin, muscles and joints. If the disease is severe and no precautions are taken, affected dogs can bleed to death after surgery or injuries. Genetic causes for Haemophilia B have been described for some cases in the breeds American Akita, Hovawart and Lhasa Apso as well.
American Akita, Hovawart, Lhasa Apso, Rhodesian Ridgeback
X chromosomal recessive
3-5 days after arrival of the sample in the lab (Rhodesian Ridgeback), 1-2 weeks after arrival of the sample in the lab (American Akita, Hovawart, Lhasa Apso)