Succinic semialdehyde dehydrogenase deficiency (SSADHD)

In the breed Saluki, a genetic variant has been found to be associated with a neurometabolic... more
Disease
In the breed Saluki, a genetic variant has been found to be associated with a neurometabolic disease called Succinic semialdehyde dehydrogenase deficiency (SSADHD). SSADHD is caused by an enzyme deficiency that impairs the metabolism of gamma-aminobutric acic (GABA), which is an important neurotransmitter of the central nervous system.
Affected puppies usually show first signs of the disease at the age of 6-10 weeks. Typical symptoms are neurological abnormalities, seizures and change in behaviour. Owners of affected puppies reported that their dogs show episodes of vocalization, a mild generalized ataxia and also lethargy, so that owners often have difficulties to wake up the puppies. Further abnormalities are absent menace reflexes in both eyes, thoracic limb hypermetria and delayed proprioceptive positioning in all four limbs. In urine, liquor and brain, elevated concentrations of gamma-hydroxybutyric (GHB) acid could be found, while the concentrations of succinic semialdehyde (SSA) are often decreased.
Because of the severe symptoms, affected puppies are often euthanized at the age of 3-9 months.
Breed
Saluki
Heredity
autosomal recessive
Test duration
1-2 weeks after arrival of the sample in the lab
We are a member:
 
Join us on
Facebook!

Newsletter
Contact