A mutation in the BHD gene was found to cause hereditary multifocal renal cystadenocarcinoma and... more
A mutation in the BHD gene was found to cause hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) in the breed German Shepherd. RCND is an autosomal dominant trait and causes bilateral, multifocal tumors in the kidney, uterine leiomyomas in female dogs and nodules in the skin consisting of dense collagen fibres in heterozygous affected dog. This mutation seems to have an embryo-lethal effect on most homozygous affected dogs, so the fetus often dies before birth.
German Shepherd Dog
3-5 days after arrival of the sample in the lab (in case of sequencing 1-2 weeks)