Characteristic and trait of inheritance
The D locus is the primary locus associated with diluted pigment, which results in coats that would otherwise be black or brown instead showing up as gray, or blue (black), and pale brown or Isabella (brown). The melanophilin gene has recently been shown to be responsible, but not all of the dilute causing mutations have yet been identified.
A recessive mutation is the cause of colour dilution phenotypes in the dog. Two alleles (variants) were described: the dominant full colour (D) and the recessive diluted colour (d). Two copies of dilute are needed to lighten black pigment to grey (often called blue), brown pigment to silver and red pigment to cream (also called buff). A diagnostic DNA test identifies the specific variants of the MLPH gene.
1-2 weeks after arrival of the sample in the lab
The DNA test is performed out of EDTA blood or buccal swabs. Required swabs can be ordered free of charge. (Buccal swab order-form). If a swab is sent in, possibly the genetic material is not sufficient to run the test. In this case it would be best to send in an EDTA blood sample.
Please send in your sample together with the lab order genetic. Results will be transmitted optionally via post, fax or email. After completion of the test you will receive a separate invoice. Payment can be made via credit card or bank transfer.
Breeding club discounts apply if a copy of the membership card is sent together with the respective samples. Due to administrative reasons the invoiced price can not be altered subsequently.